Functional Antibodies for In Vitro Organoids and Organ-on-Chip Systems

Modern New Approach Methodologies (NAMs) are reshaping translational research by replacing or complementing animal models with in vitro organoids and organ-on-chip systems that capture the complexity of living biology. These advanced 3D cultures are exquisitely sensitive: even trace contaminants such as endotoxin, carrier proteins, or sodium azide can trigger unwanted cytokine release, stress responses, or full cytokine-storm–like cascades that obscure true pathway biology.

Bio X Cell functional antibodies eliminate these artifacts at the source. Each reagent carries the same in vivo-grade quality extended into in vitro organoid and organ-on-chip systems, ultra-pure (≥ 95%) and ultra-low in endotoxin (≤ 0.5–2 EU/mg), with no BSA, preservatives, or stabilizers. This shared standard ensures reproducible activation, blockade, and depletion studies across preclinical and human-relevant models, preserving genuine biological mechanisms rather than background inflammation or cytokine noise.

With consistent lot-level QC, mg-to-g scalability, and custom formats, including recombinant, bispecific, and Fab variants, Bio X Cell antibodies provide reproducible performance from in vivo discovery through in vitro organoid validation.

Researchers modeling immune-oncology, infection, barrier integrity, or neuroinflammation can rely on Bio X Cell to minimize cytokine noise, preserve tissue viability, and generate data that truly translate across systems.

With availability from milligram to gram scales, Bio X Cell antibodies enable researchers to seamlessly transition experiments from in vivo models to in vitro and 3D systems. This continuity maximizes translational relevance, reduces variability, and helps accelerate discovery across modern research workflows.