Home Educational Resources Immune Checkpoint Antibodies

Immune Checkpoint Antibodies

Immune checkpoints are regulators of the immune system which prevent the immune system from attacking self-antigens indiscriminately. While this is critical to preventing auto-immune disease it also causes the immune system to be ineffective in eradicating or suppressing cancer. Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can be readily blocked by antibodies. Blocking these immune checkpoints allows antitumor activity to resume and is among the most promising approaches to activating therapeutic anti-tumor immunity. Bio X Cell offers an extensive selection of antibodies targeting mouse immune checkpoint proteins. Click the link below to shop all Immune Checkpoint blocking antibodies or finding your target of interest by exploring the interactive map below.